J. Anim Sci.
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J. Anim Sci. 1954. 13:912-917.
© 1954 American Society of Animal Science
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The Effects of Bacitracin, Penicillin and Arsanilic Acid on Growth Rate and Feed Efficiency in Swine1

J. H. Bridges, Fred Hale, H. O. Kunkel and Carl M. Lyman2

Texas Agricultural Experiment Station,3

Abstract

Two experiments involving 84 weanling pigs are described in which bacitracin, penicillin and Arsanilic acid singly and in combination were added to a milo-soybean oil meal ration. None of these substances significantly increased the growth rate above the control in either of the experiments. In the first experiment a small improvement in feed efficiency was obtained in the lots fed bacitracin alone, a combination of bacitracin and penicillin and a combination of bacitracin and arsanilic acid, but the differences did not prove to be statistically significant. In the second experiment, significant improvement in feed efficiency occurred in the lots fed arsanilic acid alone, penicillin alone, a combination of arsanilic acid and bacitracin, and a combination of penicillin and bacitracin.

The accumulation of arsenic in liver, kidney and muscle tissue after feeding arsanilic acid was greatest in the liver. On withdrawing arsanilic acid from the ration, the arsenic was rapidly lost from the liver, so that after 5 days the average content of As2O3 in the liver did not exceed 1 ppm.

Footnotes

1 This investigation was supported in part by a grant-in-aid from S. P. Penick and Company, New York 8, New York. Antibiotic preparations, arsanilic acid and vitamins used in the tests were also supplied by that company.

2 The authors are grateful to Dr. J. M. Prescott, O. P. Seeman and R. L. Simms for assistance in this study.

3 Departments of Biochemistry and Nutrition, and Animal Husbandry, Colllege Station, Texas.






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Copyright © 1954 by the American Society of Animal Science.