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Effects of Certain Antibiotics and Vitamin B₁₂ on Pantothenic Acid Requirements of Growing-Fattening Swine^{1, 2}

Iowa Agricultural Experiment Station

Abstract

SUPPLEE et al. (1942) showed that the pantothenic acid requirements of the pig depend on several factors, including stage of development, previous nutritional history and interrelationships with other nutrients.

Rations of natural feedstuffs were found by McMillen et al. (1948) to be low or borderline in pantothenic acid for maximum growth of pigs. Luecke et al. (1949 and 1950) produced characteristic pantothenic acid deficiencies with both semi-synthetic and natural rations containing 3.4, 3.8 and 4.2 mg. of pantothenic acid per pound of ration in the absence of added vitamin B₁₂ and antibiotics.

Vohs et al. (1950) found that 5 mcg. vitamin B₁₂ per pound of cornsoybean oil meal ration were adequate for optimum growth in growing-fattening swine. Using crystalline vitamin B₁₂, Richardson et al. (1951) reported the vitamin B₁₂ requirements of young growing pigs to be 5 mcg. or less in the presence of antibiotics (40 mg. per pound of ration). They observed an interaction between antibiotics and vitamin B₁₂.

¹ This work was supported in part by a grant from Merck & Co., Inc., Rahway, N. J. The streptomycin, penicillin and all vitamins except A, D_2, and folic acid were supplied by Merck & Co., Inc. Vitamin D₂ was supplied by Standard Brands, Inc., N. Y., N.Y.; the aureomycin and folic acid by Lederle Laboratories, Pearl River, N. Y. and the terramycin by Chas. Pfizer & Co., Inc., Brooklyn, N. Y. The authors are indebted to Dr. R. W. Luecke for the pantothenic acid assays of the experimental rations (experiment I), to Prof. E. A. Kline of the Meat Laboratory for help in collecting the carcass data, and to Mr. Don Quinn and his associates at the swine nutrition farm for their assistance.

² Journal paper no. J-2075 of the Iowa Agricultural Experiment Station, Animal Husbandry Department, Ames, Iowa. Project no. 930.