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Swine Dysentery: Treatment with 4-Nitro and 3-Nitro-4-Hydroxy Phenyl Arsonic Acids and Antibiotics^{1, 2,}

University of Minnesota

Abstract

The arsenicals, 3-nitro-4-hydroxy phenyl arsonic acid and 4-nitro-phenyl arsonic acids have a prophylactic and curative effect on swine dysentery when administered through the drinking water. Also both arsenicals and the antibiotics, aureomycin and penicillin, eliminate the outward symptoms of the disease when given orally. No treatment used prevented the recurrence of the disease.

A combination of a water medication with 4-nitro-phenyl arsonic acid and one of the antibiotics—aureomycin, terramycin, penicillin or bacitracin—as well as the 4-nitro phenyl arsonic acid in the feed was the most effective treatment in curing and preventing the recurrence of the disease under the environmental conditions imposed.

¹ Supported by grants from the Hormel Foundation, Austin, Minnesota, and Dr. Salsbury's Laboratories of Charles City, Iowa, who supplied the 3-nitro-4-hydroxy phenyl arsonic acid and the 4-nitro-phenyl arsonic acid.

² Hormel Institute publication No. 71.