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Michigan Agricultural Experiment Station
Abstract
Nutritional muscular dystrophy in the lamb was produced by using a liquid, purified vitamin E deficient diet. The symptoms of vitamin E deficiency were characterized by low total tocopherol level in blood, disturbance in locomotion, stiffness, paralysis, susceptibility to pneumonia and sudden death.
Post mortem examination showed Zenker's degeneration of the skeletal and cardiac muscle.
The lesions in the heart were invariably in the right ventricle.
Administration of 
-tocopherol alleviated the symptoms in 3–5 days to a great extent.
A complete regeneration of the muscle is no doubt a process of longer duration. Symptoms and degenerative changes of the so called "Stiff-Lambs" from the field appeared to be identical in every respect with the nutritional muscular dystrophy produced in the lamb on vitamin E deficient diet.
1 Published with the approval of the Director of the Michigan Agricultural Experiment Station as Journal Article No. 1265.
2 The data contained in this paper are a portion of the research and the theses to be presented by the senior authors (R. Culik and F. A. Bacigalupo) in partial fulfillment of the requirements for the Degree of Doctor of Philosophy, School of Graduate Studies, Michigan State College, East Lansing.
3 Departments of Agricultural Chemistry, Animal Pathology and Animal Husbandry, Michigan State College, East Lansing. The authors are indebted to Merck & Co., Inc., Rahway, New Jersey for B vitamins. This work was supported by a grant from Swift and Co., Chicago, Illinois.
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