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Effect of Nicotinic Acid, Vitamin B₁₂ and Aureomycin on Growth of Pigs and on Resistance to Artificial Infection with Salmonella Choleraesuis

U. S. Department of Agriculture

Abstract

In a pig-feeding experiment, the effects of adding nicotinic acid, vitamin B₁₂ and aureomycin, separately and in combination, to a diet low in nicotinic acid and in B₁₂, have been reported. The effects observed were as follows:

1. The addition of nicotinic acid resulted in the usual highly significant stimulation of growth.
   
2. The addition of vitamin B₁₂ was without effect.
   
3. The addition of aureomycin resulted in a highly significant stimulation of growth sharply limited to the first three weeks of the experiment.
   
4. Feeding of a broth culture of Salmonella choleraesuis at the end of the the sixth week of the experiment produced little effect on any of the pigs and no significant differences in response that could be related to the dietary treatments.
   

A possible hypothesis to account for the growth-stimulating effect of aureomycin has been suggested.

¹ The authors wish to express their appreciation of the assistance rendered by Mr. Paul Kerns in the mixing of diets and the supervision of the experimental animals.