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Pantothenic Acid Deficiency in Baby Pigs^{1, 6,}

University of Idaho

Abstract

Pantothenic acid deficiency in the young pig is characterized by poor growth, loss of appetite, scours, lachrymation, dermatitis, coughing, loss of the sucking reflex, a dark brown exudate around the eyes, spastic gait, "goose-stepping", alopecia, and low urinary excretion of pantothenic acid.

The daily feeding of one mg. of calcium pantothenate resulted in an improvement of appetite and growth and cessation of scours. There was no great improvement of the other symptoms. This was probably due to the severe depletion of the animals since they were unable to respond completely to the administration of calcium pantothenate.However, the daily supplementation of 10 to 20 mg. of calcium pantothenate resulted in complete recovery and great improvement of appetite and growth.

¹ Presented in part at the 1948 meeting of the Western Section of the American Society of Animal Production, Corvallis, Oregon, and published with the approval of the Director of the Idaho Agricultural Experiment Station as Research Paper No. 286.

⁶ We wish to acknowledge the assistance of Mrs. June Anderson and Mrs. Sybil Brislain with the vitamin analyses. Credit is due Dr. P. G. Eldredge for assistance with post mortem studies. We are also indebted to Merck and Company, Rahway, New Jersey, through the courtesy of Dr. D. F. Green, for supplies of thiamine, riboflavin, pyridoxine, nicotinic acid, inositol, choline, p-Aminobenzoic acid, biotin, calcium pantothenate and tocopherol; to Lederle Laboratories Inc., Pearl River, New York, through the courtesy of Dr. E. R. L. Stockstad, for pteroyl-glutamic acid;to E. I. Dupont De Nemours and Company, New Brunswick, New Jersey through the courtesy of Dr. S. Waddell, for crystalline vitamin D₃ and to Wilson and Company, Chicago, Illinois, through the courtesy of Dr. S. W. Hier, for the 1:20 liver powder.

² Department of Agricultural Chemistry.

³ Department of Animal Husbandry.

⁴ Present address: Department of Biochemistry, University of Louisville Medical School, Louisville, Kentucky.

⁵ Present address: Department of Animal Husbandry, University of Arizona, Tuscon, Arizona.